FAQs
Does Lokelma commonly cause diarrhea?
Diarrhea is not a common side effect of Lokelma. Clinical trials and official FDA labeling report constipation and nausea more frequently, while diarrhea is rare and usually linked to other factors.
What are the typical gastrointestinal side effects of Lokelma?
The most common gastrointestinal side effects include mild nausea and constipation. Occasionally, mild loose stools may occur but true diarrhea is uncommon.
Why might some patients experience loose stools while taking Lokelma?
Loose stools may result from preexisting digestive conditions, recent diet changes, or concurrent medications rather than Lokelma itself. For example, adding probiotics or antibiotics can affect gut flora and stool consistency.
How does Lokelma mechanistically affect the gut?
Lokelma is a potassium binder that works in the intestines by exchanging potassium for sodium and hydrogen ions. Its crystal structure is smooth and nonabsorbable, which makes it gentler on the gut compared to older treatments like Kayexalate.
What serious side effects should patients watch for when on Lokelma?
Serious side effects are rare but can include severe changes in potassium levels leading to cardiac arrhythmias, significant edema causing fluid overload, and bowel obstruction in patients with contraindications.
