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Cologuard Accuracy: What the Numbers Really Mean

Cologuard accuracy: 95% sensitivity, 12‑14% false‑positive rate, age impact, and how it compares to FIT and colonoscopy.

Cologuard Accuracy: What the Numbers Really Mean
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FAQs

What does a “positive” Cologuard result actually mean?

A positive result indicates that the test has detected DNA markers or blood that could be associated with cancer or advanced polyps. It is not a diagnosis; a follow‑up colonoscopy is required to confirm the presence of disease.

How sensitive is Cologuard for detecting colorectal cancer?

Current data show Cologuard has about 95 % sensitivity for colorectal cancer, meaning it correctly identifies roughly 95 out of 100 cancers.

What is the false‑positive rate for Cologuard and does age affect it?

The overall false‑positive rate is about 12‑14 %. It rises with age: ~10 % for ages 45‑54, 12‑13 % for 55‑64, and around 15 % for those 65 and older.

Can conditions like hemorrhoids cause a false‑positive Cologuard test?

Yes. Bleeding from hemorrhoids, anal fissures, or inflammatory bowel disease can trigger the blood‑based markers, leading to a false‑positive result.

When should I choose colonoscopy over Cologuard?

If you have a strong family history of colorectal cancer, previously identified polyps, or inflammatory bowel disease, colonoscopy is preferred because it both diagnoses and removes polyps in one visit.

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