FAQs
What symptoms may appear during donepezil withdrawal?
Common symptoms include mood swings, irritability, confusion, agitation, hallucinations, insomnia, and a possible rapid decline in cognitive function—especially if the medication is stopped abruptly[1][2][5].
How soon after stopping donepezil do withdrawal symptoms start?
Withdrawal symptoms typically emerge 3 to 7 days after discontinuation, with the most noticeable changes occurring in the first few weeks after the last dose[1][3].
What is the recommended way to taper donepezil?
Experts suggest tapering donepezil by reducing the dose 25–50% every 1–2 weeks to minimize withdrawal effects, rather than stopping abruptly[1].
How long do donepezil withdrawal symptoms last?
Withdrawal symptoms can take up to 3 weeks to resolve, but cognitive benefits may fade within 4–6 weeks after the last dose[1][2].
What should I do if severe withdrawal symptoms occur?
If severe confusion, agitation, hallucinations, delirium, or falls occur, contact your healthcare provider immediately. Restarting donepezil at the lowest dose may be considered if symptoms are distressing[1][5].
